Nanoparticles in the Lung: Environmental Exposure and Drug Delivery by Akira Tsuda and Peter Gehr
English | 2015 | ISBN: 1439892792, 1439892806 | 388 pages | PDF | 55 MB
Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger e.g., micrometer particles, are considered to behave differently when they interact with cells. The book describes the sequence of events that airborne nanoparticles encounter in the lungs when they move from air to the bloodstream. This includes deposition, events occurring on the alveolar surface (inc!. retention and clearance, interaction with surfactant and with alveolar lining fluid), crossing the air-blood tissue barrier, and finally getting into the bloodstream.